The new fonts being used here do not work nearly as well as what you were previously using, IMHO. The primary problem is that many of the fonts used in the centerblock are in general too large.
I came to the site after Dirk has already posted his comment in this topic. With that said, I don't know what you fixed, but if you saw this site through my computer, you'd be freaked out!
Before I start describing the problem, I took a look at the CSS and noticed that you've finally switched (well, mostly - there are still leftovers) from pixels to em's, but I think the problem is you've defined many of them as 1em, which is too much when you start out with a big setting (see below). I've experimented with em's and I think 0.75-0.8 is what's good for all resolutions.
The problem in this case is that I have a flat screen with a big resolution and therefore I always have IE's View=>Text Size on "Largest" so as not to ruin my eyes. When I entered this site, it looked like I saw it under a huge magnifying glass. And I'm talking huge in the sense that not even one sentence could fit on my screen! Barely one word could fit in!
I had to quickly change View=>Text Size to "Medium". Now this site looks smaller than ever before!
Changed View=>Text Size to "Larger"...still way too big! In other words, I have to switch to "Medium", view the site in a really small version and see every other site I'm currently at in a small size too because I have to be stuck at Medium!
Is this part of v1.4.1 beta? If so, we've got to fix this ASAP!
I can no longer use this site without the aforementioned manual solution (each time I enter it) and soon I won't be able to use my own sites (once I upgrade them) so would anyone take this more seriously?